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The Autoimmune Diseases - Autoimmune Diseases
Ian R. Mackay, Noel R Rose
Verlag Elsevier Reference Monographs, 2006
ISBN 9780080454740 , 1160 Seiten
4. Auflage
Format PDF, ePUB
Kopierschutz DRM
Geräte
front cover
1
copyright
5
table of contents
6
front matter
11
Editorial Advisory Board
11
Contributors
12
Reviewers
16
Acknowledgments
18
Prospectus: The Road to Autoimmune Disease
20
body
28
Section I Immunologic Basis of Autoimmunity
28
1: Autoimmunity: A History of the Early Struggle for Recognition
30
2: Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity
38
3: General Features of Autoimmune Disease
52
4: Antigen Presentation, Dendritic Cells, and Autoimmunity
64
5: Major Histocompatibility Complex and Autoimmunity
74
6: T Cells and Autoimmunity
86
7: Role of Th1 and Th2 Cells in Autoimmunity
110
8: Tolerance and Autoimmunity: T Cells
130
9: Regulatory T Cells
146
10: Peptide-Based Instruction of Suppressor Commitment in Naïve T Cells
160
11: B Cells and Autoimmunity
166
12: Memory B-Cell Development
184
13: Tolerance and Autoimmunity: B Cells
194
14: Generation of T-cell Antigenic Determinants in Autoimmunity and Their Recognition
206
15: Apoptotic Cells as a Source of Autoantigens
220
16: Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes
230
17: Functional Effects of Autoantibodies
244
18: Adhesion Molecules and Chemoattractants in the Pathogenesis and Treatment of Autoimmune Diseases
264
19: Signaling Pathways in T and B Lymphocytes
276
20: Genetics and Autoimmunity: HLA and MHC Genes
288
21: Genetics and Autoimmunity: Non-MHC Genes
300
22: Infections, Immunity, and Autoimmunity
316
23: Noninfectious Environmental Agents and Autoimmunity
324
24: Vaccines and Autoimmunity
336
25: Sex, Pregnancy, and Autoimmunity
344
26: Animal Models of Autoimmune Disease
356
Section II Autoimmune Diseases - Multisystem Diseases
376
71: Cameos
1022
70: Apoptosis and Autoimmunity: Lymphoproliferative Syndromes
1014
69: Lymphoma and Autoimmune Disease
998
68: Paraneoplastic Neurologic Diseases: Autoimmune Responses to Tumor Antigens
984
67: Idiopathic Bronchiolitis Obliterans, Idiopathic Pulmonary Fibrosis, and Autoimmune Disorders of the Lung
962
66: Large and Medium Vessel Vasculitides
948
65: Necrotizing Arteritis and Small Vessel Vasculitis
926
64: Atherosclerosis: Autoimmunity to Heat-Shock Proteins
916
63: Myocarditis and Dilated Cardiomyopathy
902
62: Rheumatic Heart Disease
890
61: Oophoritis
876
60: Orchitis and Male Infertility
868
59: Kidney Disease: Goodpasture’s Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis
848
58: Non-Bullous Skin Diseases: Alopecia, Vitiligo Psoriasis, and Urticaria
834
57: Bullous Skin Diseases: Pemphigus Pemphigoid
816
56: Pancreatitis
806
55: Primary Sclerosing Cholangitis
794
54: Primary Biliary Cirrhosis
776
53: Chronic Hepatitis
756
52: Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn’s Disease
740
51: Celiac Disease
720
50: Inner Ear Disease
708
49: Ocular Disease
696
48: Myasthenia Gravis and other Antibody-Associated Neurological Diseases
680
47: Peripheral Neuropathy
660
46: Multiple Sclerosis
642
45: Clotting Disorders
628
44: Aplastic Anemia
618
43: Neutropenia
612
42: Thrombocytopenic Purpura
602
41: Hemolytic Anemia
584
40: Hypophysitis
574
39: Gastritis and Pernicious Anemia
554
38: Polyendocrine Syndromes
542
37: Adrenalitis
528
36: Type 1 Diabetes
510
35: Thyroid Disease
494
34: Polymyositis and Dermatomyositis
480
33: Spondyloarthritis and Chronic Idiopathic Arthropathies
464
32: Rheumatoid Arthritis
444
31: Sjögren Syndrome
428
30: Antiphospholipid Syndrome
408
29: Systemic Sclerosis, Scleroderma
396
28: Systemic Lupus Erythematosus: Immunologic Features
384
27: Systemic Lupus Erythematosus and Related Diseases: Clinical Features
378
Section III Diagnosis, Prevention, and Therapy
1036
72: Autoantibody Assays, Testing, and Standardization
1038
73: T Cell Assays
1050
74: Prediction of Autoimmune Disease
1058
75: Prevention of Autoimmune Disease: Type 1 Diabetes as a Paradigm
1072
76: Emerging Therapies for Autoimmune Diseases
1090
Section IV Epilogue
1110
77: Advocatus Diaboli: What is not known about Autoimmune Disease
1112
index
1122
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