Innate Alloimmunity - Part 1: Innate Immunity and Host Defense

Preface

Acknowledgements

Contents

Abbreviations

1 Prologue: The Evolution of Oxygen Toxicity and its Role in Host Defense

1.1 Introduction

1.2 Oxygen Toxicity and Reactive Oxygen Species

1.3 Role of ROS in Microbial and Viral Pathophysiology: the Battle Between Pathogens and Host Innate Immune Cells

1.4 Outlook

1.5 References to Chapter 1

2 Innate Immunity : Some Historical Remarks

2.1 Early History :More Than 100 Years Ago

2.2 The Daw n of the Late 1960s: The Role of Macrophages in the Induction of Immune/Alloimmune Response

2.3 Recent History

2.4 Outlook

2.5 References to Chapter 2

3 Evolution of Innate Immunity

3.1 Introduction

3.2 Some Aspects of Molecular Evolution

3.3 Evolution of Innate Immune Molecules as Exemplified by TLRs and the Complement System

3.4 Evolution of Innate Immunity in Plants- Sponges, Cnidaria, and Arthopods

3.5 Outlook

3.6 References to Chapter 3

4 The Whole Family of Innate Immune Cells and Innate Humoral Factors

4.1 Introduction

4.2 The Whole Family of Innate Cells in Mammals

4.3 Innate Humoral Factors

4.4 Outlook

4.5 References to Chapter 4

5 Innate Immunity: Pattern Recognition Receptors and Their Exogenous Agonists (Ligands) in Host Defense Against Pathogens

5.1 Introduction

5.2 Mammalian Cellular PRRs, their Agonists and Signaling Pathways

5.3 PRRs and Innate (Innatelike) Lymphocytes

5.4 Mammalian Soluble Humoral PRRs and their Agonists

5.5 Outlook

5.6 References to Chapter 5

6 Innate Host Defense Peptides and Soluble Mediator Substances

6.1 Introduction

6.2 Antimicrobial Peptides

6.3 Cytokines and Chemokines

6.4 Pentraxins

6.5 Outlook

6.6 References to Chapter 6

7 Dendritic Cells: Translating Innate to Adaptive Immunity

7.1 Introduction

7.2 Function of Dendritic Cells and the Role of Maturation

7.3 DCs and Innate Lymphocytes: The Cross-Talk

7.4 Outlook

7.5 References to Chapter 7