Controversies in the Treatment of Lung Cancer - Frontiers of Radiation Therapy and Oncology, Vol. 42

Cover

Contents

Diagnostic Workup

Prognostic Factors in Histopathology ofLung Cancer

Abstract

Tumor Size: An Essential Prognostic Factor in Lung Cancer

Small Cell Lung Cancer

Prognosis and Predictive Factors in Small Cell Lung Cancer

Histological Subtype: A Prognostic Factor in NSCLC

Squamous Cell Carcinoma Histological Subtypes Associated with Poor Prognosis

Adenocarcinoma Histological Subtypes Associated with Poor Prognosis

Bronchioloalveolar Cell Carcinoma Growth Pattern: A Favorable Prognostic Factor

Large Cell Carcinomas

Prognostic Implication of Molecular Markers

Conclusion

References

FDG-PET/CT in Lung Cancer: An Update

Abstract

Non-Small Cell Lung Cancer

Staging of Lung Cancer – Distant Metastases

Prediction and Monitoring Response to Therapy

Pleural Metastases

Cost-Effectiveness

Small Cell Lung Cancer

References

Whole-Body Magnetic Resonance Imagingfor Staging of Lung Cancer

Abstract

Technical Aspects of Whole-Body MRI

Staging of Lung Cancer Using Whole-Body MRI

Conclusions

References

Bronchoscopy/Endobronchial Ultrasound

Abstract

EBUS-TBNA: Technique

Clinical Results

Complications

Conclusion

References

New Developments inVideomediastinoscopy: Video-AssistedMediastinoscopic Lymphadenectomy andMediastinoscopic Ultrasound

Abstract

Methods

Results

Comments

Implications for Clinical Practice and Further Research

References

NSCLC: Stage I/II Disease

Resection in Stage I/II Non-Small Cell LungCancer

Abstract

Surgery in Stages I and II

Conclusion

References

Role of Mediastinal Lymph Node Dissectionin Non-Small Cell Lung Cancer

Abstract

Surgical Technique of Systematic Lymph Node Dissection

Role of Nodal Involvement on Survival

Impact of Mediastinal Lymph Node Dissection on Operative Morbidity, Mortalityand Quality of Life

Diagnostic Role of Mediastinal Lymph Node Dissection

Therapeutic Role of Mediastinal Lymph Node Dissection

Conclusion

References

Radiation Therapy for Early Stage (I/II)Non-Small Cell Lung Cancer

Abstract

Radiation Therapy alone in Early Non-Small Cell Lung Cancer

Avenues for an Improvement of RT Alone in Early NSCLC

References

Stereotactic Body Radiation Therapy forEarly Non-Small Cell Lung Cancer

Abstract

Definitions of Stereotactic Body Radiation Therapy

Staging Procedures before SBRT

Implementation of Techniques in Clinical Routine

Biological Basis of Hypofractionated SBRT

Historical Aspects and Early Clinical Experience in SBRT of Lung Cancer

Clinical Experience

Follow-Up Recommendations

Future

References

NSCLC: Stage III Disease

Extended Surgical Resection in Stage IIINon-Small Cell Lung Cancer

Abstract

Discussion of Stage-Related Treatment

Conclusions

References

Stage III: Definitive Chemoradiotherapy

Abstract

Optimization of Combined Radiotherapy and Chemotherapy

Which Chemotherapy and Radiotherapy Regimens Are Optimal for ConcurrentChemoradiotherapy?

How Do Comorbidities Influence the Performance of ConcurrentChemoradiotherapy?

References

Adjuvant Therapy in Early-Stage Non-SmallCell Lung Cancer

Abstract

Landmark Studies Concerning Adjuvant Platinum-Based Chemotherapy

Negative Studies

The LACE (Lung Adjuvant Cisplatin Evaluation) Meta-Analysis (table 2)

Adjuvant Chemotherapy and Stage (table 3)

Which Chemotherapy Combination?

Adjuvant Radiotherapy

Patient Selection and Predictive or Prognostic Factors

Neoadjuvant Chemotherapy

Conclusion

References

Postoperative Irradiation in Non-Small CellLung Cancer

Abstract

References

Altered Fractionation Schemes inRadiotherapy

Abstract

Hypofractionated Stereotactic Body Radiotherapy for NSCLC (Stage I)

Hyperfractionated Accelerated Radiotherapy for Stage III NSCLC

References

NSCLC: Palliative Procedures in Stage IV

Chemotherapy of Advanced Non-Small CellLung Cancer

Abstract

Pemetrexed

Cisplatin- vs. Carboplatin-Based Chemotherapy

Elderly Patients and Patients with Reduced Performance Status

Customized Chemotherapy

Targeted Therapies

Maintenance Therapy

Systemic Chemotherapy in Patients Progressing after First-Line Chemotherapy

Assessment of Efficacy

References

Radiotherapy

Abstract

Clinical Manifestations of Advanced Lung Carcinoma

Palliative Potential of Radiotherapy

Treatment Strategies

References

Small Cell Lung Cancer

Treatment of Limited Disease Small CellLung Cancer

Abstract

Thoracic Radiotherapy

Patient Selection

Future Perspectives

References

Radiochemotherapy in Extensive DiseaseSmall Cell Lung Cancer ED-SCLC

Abstract

RT in ED-SCLC Trial

Future Approaches

Conclusions

References

Radiotherapy for Extensive Stage SmallCell Lung Cancer

Abstract

Introduction

Brain Metastases

Prophylactic Cranial Irradiation

Thoracic Radiotherapy

References

Controversies in the Treatment ofAdvanced Stages of Small Cell Lung Cancer

Abstract

First-Line Chemotherapy

Prophylactic Cranial Irradiation after First-Line Chemotherapy

Second-Line Chemotherapy

References

Use of Complementary and Alternative Medicine in Lung Cancer

Complementary and Alternative Medicinein Lung Cancer Patients: A Neglected Phenomenon?

Abstract

Methods

Results

Discussion

Conclusions

References

Author Index

Subject Index