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Principles and Applications of Magnetic Particle Imaging
Bernhard Gleich
Verlag Springer Vieweg, 2013
ISBN 9783658019617 , 118 Seiten
Format PDF, OL
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Preface by the Series Editor
6
Foreword
7
Contents
8
1 Introduction
11
2 Medical imaging methods
14
2.1 Signal penetration
15
2.2 Tissue interaction
17
2.3 Signal confinement/resolution
18
2.4 Overview of existing imaging methods
20
2.5 Conclusions for successful new imaging modalities
24
3 Basic idea of Magnetic Particle Imaging
27
3.1 Signal generation and recording
27
3.1.1 Signal generation
3.1.1 Signal generation
3.1.2 Signal confinement
31
3.1.3 Drive field
33
3.2 Reconstruction
35
4 Magnetic particle properties
40
4.1 Demagnetization factor
4.1 Demagnetization factor
4.2 Single domain particles and the Langevin theory
43
4.3 Remagnetization processes
45
4.4 Magnetic anisotropy
47
4.5 Particle–particle interactions
50
5 The Focus Field
52
5.1 Patient safety
52
5.2 Technical limitations
53
5.3 Additional fields, the focus fields
53
6 Resolution, sensitivity and speed
55
6.1 Unlimited resolution?
55
6.2 Sensitivity
57
6.2.1 Signal strength
58
6.2.2 Patient noise
58
6.2.3 Detection limit of MPI
59
6.2.4 Detection limit of MRI
60
6.2.5 Detection limit of CT
60
6.2.6 Detection limit of PET and SPECT
62
6.3 Encoding efficiency
63
6.4 Speed limit
71
6.4.1 MPI encoding speed
71
6.4.2 Ultrasound encoding speed
72
6.4.3 CT encoding speed
72
6.4.4 MRI encoding speed
73
7 Experimental and simulation results on MPI
75
8 Potential applications of MPI
79
8.1 Combination with magnetic resonance imaging
79
8.2 Vascular applications
82
8.2.1 Cardiovascular
83
8.2.2 Neurovascular
85
8.3 Gastrointestinal
86
8.4 Lung
87
8.5 RES imaging/direct inflammation imaging
87
8.6 Cell labelling
88
8.6.1 Red blood cell labelling
88
8.6.2 White blood cell labelling
89
8.6.3 Stem cell labelling
90
8.7 Sentinel lymph node imaging
90
8.8 Hyperthermia
91
9 Potential further developments and applications
93
9.1 Tissue intrinsic contrast MPI
93
9.2 Targeted imaging
93
9.3 Lung diffusion imaging
94
9.4 Temperature imaging
95
9.5 MPI-acoustic imaging and Elastography
97
9.6 Pulmonary artery pressure
98
9.7 Object tracking and manipulation
100
9.8 Electrophysiology imaging
102
9.9 Light modulation
104
9.10 X-ray modulation
105
9.11 Targeted drug delivery
105
10 Conclusion
107
Bibliography
112
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