dummies
 

Suchen und Finden

Titel

Autor/Verlag

Inhaltsverzeichnis

Nur ebooks mit Firmenlizenz anzeigen:

 

Epigenetic Therapy of Cancer - Preclinical Models and Treatment Approaches

Michael Lübbert, Peter A. Jones

 

Verlag Springer-Verlag, 2013

ISBN 9783642384042 , 325 Seiten

Format PDF

Kopierschutz Wasserzeichen

Geräte

96,29 EUR


 

The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.