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DNA Repair and Human Disease
Adayabalam Balajee
Verlag Springer-Verlag, 2007
ISBN 9780387368023 , 161 Seiten
Format PDF, OL
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CONTENTS
5
EDITOR
8
CONTRIBUTORS
8
PREFACE
10
Human Premature Aging Disorders and Dysfunction of DNA Repair
12
DNA Repair Aspects for RecQ Helicase Disorders
31
Trichothiodystrophy: A Disorder Highlighting the Crosstalk between DNA Repair and Transcription
41
Roles of the BRCAl and BRCA2 Breast Gmcer Susceptibility Proteins in DNA Repair
58
Radiosensitivity of Cells Derived from Down Syndrome Patients: Is Defective DNA Repair Involved?
72
The Fanconi Anemia/BRCA Pathway. FANCD2 at the Crossroad between Repair and Checkpoint Responses to DNA Damage
78
Is Ataxia Telangiectasia a Result of Impaired Coordination between DNA Repair and Cell Cycle Checkpoint Regulators?
93
Mechanisms of DNA Damage and Repair in Alzheimer Disease
109
Orchestration of Telomeres and DNA Repair Factors in Mammalian Cells: Implications for Cancer and Ageing
125
Defective Solar Protection in Xeroderma Pigmentosum and Cockayne Syndrome Patients
139
Index
158
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