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Current Hypotheses and Research Milestones in Alzheimer's Disease
Ricardo B. Maccioni, George Perry
Verlag Springer-Verlag, 2009
ISBN 9780387879956 , 254 Seiten
Format PDF, OL
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Preface
5
Contents
7
Role of A b Degrading Enzymes in SynapticPlasticity and Neurogenesis in Alzheimer’sDisease
11
Pore- Forming Neurotoxin-Like Mechanismfor A b Oligomer-Induced Synaptic Failure
21
Interventions in Aging and Neurodegenerative Disease: Effects on Adult Stem Cells
30
Tau Transgenic Mouse Models in Therapeutic Development
46
What Have We Learned from the Tau Hypothesis?
54
Neuronal Cytoskeleton Regulation and Neurodegeneration
68
Stages of Pathological Tau-Protein Processing in Alzheimer’s Disease: From Soluble Aggregations to Polymerization into Insoluble Tau- PHFs
84
Plasma Membrane-Associated PHF-Core Could be the Trigger for Tau Aggregation in Alzheimer’s Disease
97
Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer’s Disease
106
Inflammatory Processes Exacerbate Degenerative Neurological Disorders
118
Central Nervous System Inflammation and Cholesterol Metabolism Alterations in the Pathogenesis of Alzheimer’s Disease and Their Diagnostic and Therapeutic Implications
126
Participation of Glial Cells in the Pathogenesis of AD: A Different View on Neuroinflammation
139
Cerebral and Cardiac Vascular Pathology in Alzheimer’s Disease
158
Are Amyloids Infectious?
169
The Possible Link Between Herpes Simplex Virus Type 1 Infection and Neurodegeneration
179
How Biochemical Pathways for Disease May be Triggered by Early- Life Events
202
Strategies for Alzheimer’s Disease Diagnosis
213
The Diagnosis of Dementia in Subjects with Heterogeneous Educational Levels
224
Current Anti-Dementia Drugs: Hypothesis and Clinical Benefits
232
Index
238
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