National Institute of Allergy and Infectious Diseases, NIH - Volume 3: Intramural Research

Foreword

Contents

Contributors

Microbiology: Virology

The Evolution of Gammaretrovirus Restriction Factors in the Mouse

Herpesvirus Research at the National Institute of Allergy and Infectious Diseases: Thirty Years of Progress

Why Study Mouse Retroviruses?

Functions of the Rotavirus RNA Polymerase in Virus Replication

Human T-Cell Leukemia Virus Type 1, Cellular Transformation, and Adult T- Cell Leukemia

Microbiology: Human Immunodeficiency Virus (Hiv)

Roles for Chemokine Receptors in HIV Pathogenesis

HIV-1 Accessory Proteins: Crucial Elements for Virus- Host Interactions

Microbiology: Bacteriology

Exploring the Cause of Human Q Fever: Recent Advances in Coxiella burnetii Research

Plague in the 21st Century: Global Public Health Challenges and Goals

Molecular Biology of Staphylococcal Pathogenesis

Investigations of Relapsing Fever at Home and Abroad

Molecular Sleuthing with the Lyme Disease Agent

Modeling of Acute Respiratory Melioidosis and Glanders

Microbiology: Mycology

Cryptococcosis: From Discovering the Natural Reservoir of its Etiology to the Genetic Manipulation of Cryptococcus neoformans: Milestones in Cryptococcal Research by Intramural Investigators at NIAID

Microbiology: Parasitology

Lessons from Parasites on CD4+ T-Cell Subset Differentiation and Function

Molecular Aspects of Parasite – Vector Interactions In Leishmaniasis

Microbiology: Malaria

Mosquito Strategies Against Plasmodium: A Tale of Restrained Response and Immune Evasion

The Plasmodial Surface Anion Channel: A Model Microbial Ion Channel and Target for Antimalarial Drug Development

Genomics and Genetics of Drug Resistance and Regulation of Malaria Parasite Development

Immunology: Cellular Immunology

Modulation of Human Dendritic Cells by Highly Virulent Pathogens

Making Friends in Out-of-the- Way Places: How Cells of the Immune System Get Together and How They Conduct Their Business as Revealed by Intravital Imaging

Role of Regulatory/Suppressor T Cells in Immune Responses

Proliferation versus Contraction of Immune Cells, the Non-Apoptotic Role of Caspase 8 In Immune Homeostasis

Features of Plasma Cell-Related Neoplasms in Mice

A Role of IRF8 in Transcriptional Control of B-Cell Development

Laboratory of Molecular Immunology

Immunology: The Role of Receptors

Structure and Function of Immunoreceptors

Role of the NKG2D Receptor in Health and Disease

Allergy

G-Protein-Evoked Signaling Mechanisms in Asthma and Allergic Disease

Mast Cell Precursors and Signaling Pathways

Clinical Medicine: Infectious Diseases

Prion Biochemistry and Therapeutics

Neutrophils in the Resolution of Infection

Reactive Oxidant-Dependent Innate Immune Defenses of the Airway Epithelium: The Dual Oxidase- Lactoperoxidase- Thiocyanate System

Chronic Granulomatous Disease: From Lethal Pediatric Mystery to Complex Chronic Disease

Pneumonia Virus of Mice (PVM): Exploring Novel Therapeutic Options In a Severe Respiratory Disease Model

The 1918 Influenza Pandemic: Pathology and Pathogenesis

Clinical Medicine: Autoimmune Diseases

Mind Your Xs and Ys: Genetics of the Autoimmune Disease Systemic Lupus Erythematosus

A Bench-to-Bedside Trail of Research Leading to the Understanding and Treatment of Ulcerative Colitis

Clinical Medicine: Vaccines

Structural Biology and the Design of Effective Vaccines for HIV- 1 and Other Viruses

How Do You Say “B-Cell Biology” In “Vaccinology”: Translational Research In the NIAID

Malaria Vaccine Development

The Development of Live-Attenuated Vaccines for Pandemic Influenza

Targeting the Messenger: Vector-Based Vaccines to Control Leishmania Infection and Transmission

Index