Advances in Pharmacology

Front Cover

Advances in Pharmacology, Volume 30

Copyright Page

Contents

Contributors

Chapter 1. Neuroprotective Actions of Excitatory Amino Acid Receptor Antagonists

I. Introduction

II. Glutamate Receptor Subtypes

III. Excitotoxicity and Glutamate

IV. Ischemia

V. Prospects for Clinical Application

VI. Molecular Events Associated with Neuroprotection

VII. Conclusions

References

Chapter 2. Pharmacologic Therapy of Obsessive Compulsive Disorder

I. Clinical Features of Obsessive Compulsive Disorder

II. Biology of OCD

III. Pharmacologic Treatment of OCD

IV. Summary

References

Chapter 3. Mechanism of Action of Antibiotics in Chronic Pulmonary Pseudomonas Infection

I. Introduction

II. Bacterial Biofilms

III. Pseudomonas aeruginosa in Cystic Fibrosis

IV. Antibiotic Therapy of Intermittent and Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis

V. Conclusions

References

Chapter 4. Quinolinic Acid in Neurological Disease: Opportunities for Novel Drug Discovery

I. General Properties of Quinolinic Acid

II. Neurotoxicity of Quinolinic Acid

III. Pathways for Quinolinic Acid Biosynthesis

IV. Sites of Control of Quinolinic Acid Biosynthesis

V. Studies on Quinolinate in Vivo

VI. lnhibitors of Quinolinic Acid Biosynthesis

VII. Implications for Drug Discovery

References

Chapter 5. Pharmacologic Management of Shock-Induced Renal Dysfunction

I. Introduction to Shock

II. Spectrum of Renal Dysfunction in Shock

III. Pathophysiology of Acute Renal Failure in Shock

IV. Pharmacologic Measures

V. Conclusion

References

Chapter 6. Autoantibodies against Cytochromes P450: Role in Human Diseases

I. Introduction

II. Diseases for Which No Causative Toxin Was Identified

III. Diseases for Which a Causative Drug Has Been Identified

IV. Hypotheses for the Appearance and Role of Anti-P450 Autoantibodies

V. Conclusions

References

Chapter 7. Activation and Inactivation of Gene Expression Using RNA Sequences

I. Introduction

II. Examples of RNA-Mediated Gene Regulation

III. Pharmacological Applications of RNAs

IV. Concluding Remarks

References

Chapter 8. Therapy of Cancer Metastasis by Systemic Activation of Macrophages

I. Introduction

II. Cancer Metastasis

III. Macrophages and Homeostasis

IV. Tumoricidal Activation of Macrophages

V. Macrophage–Tumor Cell Interaction

VI. Mechanisms for Macrophage Recognition of Tumor Cells

VII. Systemic Activation of Macrophages by Liposomes Containing Immunomodulators

VIII. Macrophage Infiltration into Tumors

IX. Therapy of Cancer Metastasis in Murine Models

X. Optimization and Limitations of Systemic Macrophage Activation-Based Therapy

XI. Potentiation of Macrophage Activation for Treatment of Cancer Metastases with Liposome-Encapsulated Agents

XII. Multimodality Treatment of Lung Metastases in Murine Models

XIII. Therapy of Spontaneous Lung Metastases in Dogs with Osteogenic Sarcoma

XIV. Clinical Studies

XV. The Place of Macrophage Systemic Activation in Multimodality Protocols

XVI. Conclusions

References

Chapter 9. 5-Hydroxytryptamine Receptor Subtypes: Molecular and Functional Diversity

I. Introduction

II. G-Protein-Coupled 5-HT Receptors

III. 5-HT-Gated Ion Channels-5-HT3 Receptors

IV. Conclusion

References

Index

Contents of Previous Volumes