The Autoimmune Diseases - Autoimmune Diseases

front cover

copyright

table of contents

front matter

Editorial Advisory Board

Contributors

Reviewers

Acknowledgments

Prospectus: The Road to Autoimmune Disease

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Section I Immunologic Basis of Autoimmunity

1: Autoimmunity: A History of the Early Struggle for Recognition

2: Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity

3: General Features of Autoimmune Disease

4: Antigen Presentation, Dendritic Cells, and Autoimmunity

5: Major Histocompatibility Complex and Autoimmunity

6: T Cells and Autoimmunity

7: Role of Th1 and Th2 Cells in Autoimmunity

8: Tolerance and Autoimmunity: T Cells

9: Regulatory T Cells

10: Peptide-Based Instruction of Suppressor Commitment in Naïve T Cells

11: B Cells and Autoimmunity

12: Memory B-Cell Development

13: Tolerance and Autoimmunity: B Cells

14: Generation of T-cell Antigenic Determinants in Autoimmunity and Their Recognition

15: Apoptotic Cells as a Source of Autoantigens

16: Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes

17: Functional Effects of Autoantibodies

18: Adhesion Molecules and Chemoattractants in the Pathogenesis and Treatment of Autoimmune Diseases

19: Signaling Pathways in T and B Lymphocytes

20: Genetics and Autoimmunity: HLA and MHC Genes

21: Genetics and Autoimmunity: Non-MHC Genes

22: Infections, Immunity, and Autoimmunity

23: Noninfectious Environmental Agents and Autoimmunity

24: Vaccines and Autoimmunity

25: Sex, Pregnancy, and Autoimmunity

26: Animal Models of Autoimmune Disease

Section II Autoimmune Diseases - Multisystem Diseases

71: Cameos

70: Apoptosis and Autoimmunity: Lymphoproliferative Syndromes

69: Lymphoma and Autoimmune Disease

68: Paraneoplastic Neurologic Diseases: Autoimmune Responses to Tumor Antigens

67: Idiopathic Bronchiolitis Obliterans, Idiopathic Pulmonary Fibrosis, and Autoimmune Disorders of the Lung

66: Large and Medium Vessel Vasculitides

65: Necrotizing Arteritis and Small Vessel Vasculitis

64: Atherosclerosis: Autoimmunity to Heat-Shock Proteins

63: Myocarditis and Dilated Cardiomyopathy

62: Rheumatic Heart Disease

61: Oophoritis

60: Orchitis and Male Infertility

59: Kidney Disease: Goodpasture’s Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis

58: Non-Bullous Skin Diseases: Alopecia, Vitiligo Psoriasis, and Urticaria

57: Bullous Skin Diseases: Pemphigus Pemphigoid

56: Pancreatitis

55: Primary Sclerosing Cholangitis

54: Primary Biliary Cirrhosis

53: Chronic Hepatitis

52: Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn’s Disease

51: Celiac Disease

50: Inner Ear Disease

49: Ocular Disease

48: Myasthenia Gravis and other Antibody-Associated Neurological Diseases

47: Peripheral Neuropathy

46: Multiple Sclerosis

45: Clotting Disorders

44: Aplastic Anemia

43: Neutropenia

42: Thrombocytopenic Purpura

41: Hemolytic Anemia

40: Hypophysitis

39: Gastritis and Pernicious Anemia

38: Polyendocrine Syndromes

37: Adrenalitis

36: Type 1 Diabetes

35: Thyroid Disease

34: Polymyositis and Dermatomyositis

33: Spondyloarthritis and Chronic Idiopathic Arthropathies

32: Rheumatoid Arthritis

31: Sjögren Syndrome

30: Antiphospholipid Syndrome

29: Systemic Sclerosis, Scleroderma

28: Systemic Lupus Erythematosus: Immunologic Features

27: Systemic Lupus Erythematosus and Related Diseases: Clinical Features

Section III Diagnosis, Prevention, and Therapy

72: Autoantibody Assays, Testing, and Standardization

73: T Cell Assays

74: Prediction of Autoimmune Disease

75: Prevention of Autoimmune Disease: Type 1 Diabetes as a Paradigm

76: Emerging Therapies for Autoimmune Diseases

Section IV Epilogue

77: Advocatus Diaboli: What is not known about Autoimmune Disease

index